Fermentation Finds Fresh Momentum in Global Hubs

Rising demand for fermentation based proteins and bioproducts is prompting CMOs including Lonza to grow microbial capacity

3 Dec 2025

Microbial fermentation is slipping back into the spotlight in many biomanufacturing hubs. Developers are rediscovering its value for enzymes, peptides, simple proteins and an expanding set of chemical intermediates. No one expects it to supplant mammalian systems, but it offers a practical route for molecules that do not need the intricate modifications those cells provide.

Recent moves show this return taking shape. Lonza plans to boost microbial capacity at its Visp site in Switzerland, a signal that fermentation still anchors global production strategies. Other contract manufacturers are updating older suites or adding compact new ones equipped with fresh automation and digital monitoring tools that trim variability and speed routine work.

Market analysts see this measured growth continuing. Forecasts point to a slow climb in demand through the next decade, driven by specialty enzymes, climate focused chemicals and select biologic intermediates. The trajectory suggests momentum rather than upheaval, with activity concentrating where fermentation delivers a clear technical or economic advantage. One firm noted that only 1 percent of its pipeline hinged on mammalian style changes, a reminder of how often fermentation fits the brief.

Developers are also rethinking how fermentation can shorten development paths. Its scalability and long regulatory history help projects move forward when post translational modifications are not central. Trade coverage, including reporting from GeneOnline, has followed this cautious modernization as CMOs adjust capacity to match targeted needs.

Challenges still shape the field. Access to purpose built suites can be uneven, and some companies struggle to secure production slots. Talent shortages and shifting regulatory expectations add more friction, prompting CMOs to favor incremental expansion over large bets on new infrastructure.

Taken together, these signals point to a focused but growing role for microbial fermentation. As facilities improve and demand rises for products that suit the platform, CMOs are positioning fermentation as a steady pillar within a broader and more diversified biomanufacturing ecosystem.